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Dicoumarol ，≥98%

Q0203G
3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one) 3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one) Show
66-76-2
RT避光
1年
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Catalog No. Specification List Price Preferential Price VIP Beijing Harbin Shenyang Guangzhou Quantity Cart
Q0203G 1g $32.75
Product Name Dicoumarol
Alias 3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one)
CAS No. 66-76-2
Molecular Formula C19H12O6
Molecular Weight 336.29
Solubility 溶于吡啶(50mg/ml)
Purity： ≥98%
Introduction：

一种NAD(P)H:醌氧化还原酶1(NQO1)和PDK1的抑制剂。

Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases. Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vitamin K directly—as they are in pharmaceutical uses—but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test.

These protocols are for reference only. Biotopped does not independently validate these methods.

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