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Semaglutide ，≥98%

Q60123G
Rybelsus;Ozempic;NN9535;OG217SC;NNC 0113-0217 Rybelsus;Ozempic;NN9535;OG217SC;NNC 0113-0217 Show
910463-68-2
-20°C
3年
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Catalog No. Specification List Price Preferential Price VIP Beijing Harbin Shenyang Guangzhou Quantity Cart
Q60123G 1mg $17.34
Q60123G 5mg $64.40
Q60123G 25mg $196.77
Q60123G 100mg $616.45
Product Name Semaglutide
Alias Rybelsus;Ozempic;NN9535;OG217SC;NNC 0113-0217
CAS No. 910463-68-2
Molecular Formula C187H291N45O59
Molecular Weight 4113.58
Solubility DMSO :5 mg/mL (1.22 mM; ultrasonic and warming and heat to 60°C)
Water：12.5 mg/mL (3.04 mM; ultrasonic and adjust pH to 2 with HCl)
Purity： ≥98%
Introduction：

Semaglutide 是人胰高血糖素样肽-1 的一个长效类似物， 是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂。Semaglutide 有潜力用于 2 型糖尿病的研究。

 

靶点：GLP-1 receptor

 

储备液保存：

-80°C, 6 months

-20°C, 1 month

 (sealed storage, away from moisture)

 

 体外研究：

Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06 nM. Semaglutide is a GLP-1 analogue with 94% sequence omology to human GLP-1.

 

体内研究：

The plasma half-life of Semaglutide is 46h in mini-pigs following i.v. administration and semaglutide has an MRT of 63.6h after s.c. dosing to mini-pigs. Semaglutide improves 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced motor impairments. In addition, Semaglutide rescues the decrease of tyrosine hydroxylase (TH) levels, alleviates the inflammation response, reduces lipid peroxidation, inhibits the apoptosis pathway, and also increases autophagy- related protein expression, to protect dopaminergic neurons in the substantia nigra and striatum. Moreover, the long-acting GLP-1 analogue semaglutide is superior to NN-2211 in most parameters.

 

注意事项：

1.为了您的安全和健康，请穿实验服并戴一次性手套操作。

2.本产品为钠盐形式。

3.以上信息仅做参考交流之用。

These protocols are for reference only. Biotopped does not independently validate these methods.

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