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Ferrostatin-1 (Fer-1) ，99.80%

Q0219G
347174-05-4
-20℃
3年
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Catalog No. Specification List Price Preferential Price VIP Beijing Harbin Shenyang Guangzhou Quantity Cart
Q0219G 2mg $66.87
Product Name Ferrostatin-1 (Fer-1)
Alias Benzoic acid, 3-amino-4-(cyclohexylamino)-, ethyl ester
CAS No. 347174-05-4
Molecular Formula C15H22N2O2
Molecular Weight 262.35
Solubility DMSO : 125 mg/mL (476.46 mM; Need ultrasonic)溶液稳定性不好，建议现配现用
Purity： 99.80%
Introduction：

产品描述：

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity

 

靶点：

EC50: 60 nM (Ferroptosis);Ferroptosis; Antifungal

 

体内研究：

Ferrostatin-1 inhibits cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction. Ferrostatin-1 (0.8 mg/kg; tail vein injection) effectively alleviates LPS-induced induced acute lung injury (ALI). Ferrostatin-1 (i.p.; 5 mg/kg; C57BL/6J mice) improves renal function in mice with rhabdomyolysis

These protocols are for reference only. Biotopped does not independently validate these methods.

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